Vesicant: A substance that causes tissue blistering. A blister agent. Also called a vesicatory.Vesicants are highly reactive chemicals that combine with proteins, DNA, and other cellular components to result in cellular changes immediately after exposure. Vesicants can be used as agents of chemical warfare, as was the case in World War I, or as age... Found on http://www.medterms.com/script/main/art.asp?articlekey=11549