[biology] In biology and biochemistry, protease inhibitors are molecules that inhibit the function of proteases. Many naturally occurring protease inhibitors are proteins. In medicine, protease inhibitor is often used interchangeably with alpha 1-antitrypsin (A1AT, which is abbreviated PI for this reason). A1AT is indeed the protease inhibi...
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http://en.wikipedia.org/wiki/Protease_inhibitor_(biology)
[pharmacology] Protease inhibitors (PIs) are a class of antiviral drugs that are widely used to treat HIV/AIDS and hepatitis caused by hepatitis C virus. Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for...
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http://en.wikipedia.org/wiki/Protease_inhibitor_(pharmacology)
(from the article `drug`) Protease inhibitors (e.g., ritonavir, saquinavir, and indinavir) block the spread of HIV to uninfected cells by inhibiting the viral enzymes involved ... ...drug use and to discourage the sharing of needles have also led to a reduction in infection rates in some areas. HIV infection is treated with ... [2 re...
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http://www.britannica.com/eb/a-z/p/122
A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading.
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http://www.cancer.gov/dictionary?expand=P
A drug that binds to and blocks HIV protease from working, thus preventing the production of new infectious viral articles. ... (09 Oct 1997) ...
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http://www.encyclo.co.uk/local/20973
a substance that blocks activity of endopeptidase (protease), such as in a virus. HIV protease inhibitor.
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http://www.encyclo.co.uk/local/21001
an agent that inhibits viral replication by interfering with the virus' protease enzyme. HCV protease inhibitors include boceprevir and telaprevir.
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http://www.encyclo.co.uk/local/22225
Type: Term Definitions: 1. a class of synthetic drug used in the treatment of human immunodeficiency virus (HIV-1) infection.
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http://www.medilexicon.com/medicaldictionary.php?t=44662
Protease inhibitor: One of a class of anti-HIV drugs designed to inhibit the enzyme protease and thereby interfere with virus replication. Protease inhibitors prevent proteases from splitting proteins into peptides. Protease inhibitors prevent the cleavage of HIV precursor proteins into active proteins, a process that normally occurs when HIV repli...
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http://www.medterms.com/script/main/art.asp?articlekey=5080
A new class of experimental antiretroviral drugs that work by inhibiting the HIV protease. Some examples include Saquinavir, Indinavir, and Ritonavir.
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http://www.virology.net/ATVGlossary.html
one of a class of anti-HIV drugs designed to inhibit the enzyme protease and interfere with virus replication. Protease inhibitors prevent the cleavage of HIV precursor proteins into active proteins, a process that normally occurs when HIV replicates.
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https://aidsinfo.nih.gov/news/128/hiv-vaccine-glossary
class of antiviral drugs, used in HIV therapy and hepatitis C therapy, that inhibits viral-specific proteases, preventing viral maturation
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https://courses.lumenlearning.com/microbiology/chapter/glossary/
PI noun an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs
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https://www.encyclo.co.uk/local/20974
No exact match found.
