1) Aggravation 2) Intensification 3) Medical terminology 1) Aggravation 
• (n.) A periodical increase of violence in a disease, as in remittent or continious fever; an increased energy of diseased and painful action. • (n.) The act rendering more violent or bitter; the state of being exacerbated or intensified in violence or malignity; as, exacerbation of passion.
(ex- + L. acerbus harsh) increase in the severity of a disease of its symptoms.
The relapse of a chronic condition.
An increase in the severity of a disease of its symptoms. ... (18 Nov 1997) ... 
(eg-zas″әr-ba´shәn) increase in severity of a disease or any of its symptoms.
A deterioration in a condition, usually an acute episode of a chronic illness e.g. an acute episode of infection in chronic lung conditions or a flare up of joint problems in rheumatoid disease
Ex·ac`er·ba'tion noun [ Confer French exacerbation .] 1. The act rendering more violent or bitter; the state of being exacerbated or intensified in violence or malignity; as, exacerbation of passion. 2. (Medicine) A periodical increase of violence in a disease, as...
Increase in severity of a disease or in the violence of symptoms.
Type: Term Pronunciation: ek-zas′ĕr-bā′shŭn, ek-sas- Definitions: 1. Increased severity of a disease or any of its signs or symptoms.
Exacerbation: A worsening. In medicine, exacerbation may refer to an increase in the severity of a disease or its signs and symptoms. For example, exacerbation of asthma is one of the serious effects of air pollution..
[n] - violent and bitter exasperation
exacerbation Increase in the severity of a disease or any of its symptoms, as in a continuous fever.
noun violent and bitter exasperation; `his foolishness was followed by an exacerbation of their quarrel`
action that makes a problem or a disease worse