It was discovered via a lengthy trial-and-error search for a more stable version of the natural product thienamycin, which is produced by the bacterium Streptomyces cattleya. Thienamycin has antibacterial activity, but is unstable in aqueous solution, so impractical to administer to patients. Imipenem has a broad spectrum of activity against aerob...
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http://en.wikipedia.org/wiki/Imipenem
(from the article `drug`) Imipenem is a -lactam antibiotic that works by interfering with cell wall synthesis. It is highly resistant to hydrolysis by most -lactamases. This ...
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http://www.britannica.com/eb/a-z/i/10
An antibiotic drug used to treat severe or very resistant infection. It belongs to the family of drugs called carbapenems.
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http://www.cancer.gov/dictionary?expand=I
<chemical> 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7- oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid. Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases....
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http://www.encyclo.co.uk/local/20973
(im″ĭ-pen´әm) a β-lactam antibiotic with a broad spectrum of activity against gram-positive and gram-negative organisms. Because it is metabolized in the kidneys, it is administered with the enzyme inhibitor cilastatin in order to decrease the amount of it that is degraded by an enzyme in the kidne...
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http://www.encyclo.co.uk/local/21001
Type: Term Pronunciation: im′i-pen′em Definitions: 1. A beta-lactam antibiotic derived from thienamycin with broad spectrum activity used, in combination with cilastin, to treat various infections. Classified as a carbapenem antibiotic.
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http://www.medilexicon.com/medicaldictionary.php?t=43634
No exact match found.
