Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the production of platelets. It stimulates the production and differentiation of megakaryocytes, the bone marrow ce...
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http://en.wikipedia.org/wiki/Thrombopoietin
(from the article `blood`) ...by reticuloendothelial cells (any of the tissue phagocytes). The rate of platelet production is controlled but not so precisely as the control of ...
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http://www.britannica.com/eb/a-z/t/45
A substance made by the body that helps make blood cells, especially platelets. A form of thrombopoietin made in the laboratory is called recombinant human thrombopoietin and rHu thrombopoietin. Thrombopoietin is being studied as a way to increase the number of platelets in cancer patients receiving chemotherapy. Also called TPO.
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http://www.cancer.gov/dictionary?expand=T
<chemical> A humoral factor that controls blood platelet production through stimulation of megakaryocyte populations. Bone marrow megakaryocytes increase in both size and number in response to exposure to thrombopoietin. ... Chemical name: Thrombopoietin ... (12 Dec 1998) ...
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http://www.encyclo.co.uk/local/20973
(throm″bo-poi´ә-tin) a colony-stimulating factor that is the humoral regulator of the production of platelets.
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http://www.encyclo.co.uk/local/21001
Growth factor (19D) that regulates the proliferation of megakaryocytes and production of platelets (thrombopoiesis). Receptor is c-mpl, a cytokine receptor that can cause phosphorylation of STAT3 and STAT5 through Jak3.
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Type: Term Pronunciation: throm′bō-poy′ĕ-tin Definitions: 1. A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1. Synonyms: megakaryocyte growth and development factor, megapoietin
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http://www.medilexicon.com/medicaldictionary.php?t=91842
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