==Mechanism of action== Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. The cytotoxic effects of teniposide are related to ...
Found on
http://en.wikipedia.org/wiki/Teniposide
An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.
Found on
http://www.cancer.gov/dictionary?expand=T
<chemical> A cytotoxic semisynthetic derivative of podophyllotoxin that may be effective in cancer chemotherapy. It prevents cells from entering the prophase of mitosis and inhibits DNA synthesis. ... Pharmacological action: antineoplastic agent, phytogenic, nucleic acid synthesis inhibitors. ... Chemical name: Furo(3',4':6,7)naphtho(2,3-d)-1...
Found on
http://www.encyclo.co.uk/local/20973
(VM-26) (ten-ĭ-po´sīd) a semisynthetic derivative of podophyllotoxin, administered orally as an antineoplastic agent in treatment of neuroblastoma, non-Hodgkin lymphoma, and acute lymphoblastic leukemia; administered intravenously.
Found on
http://www.encyclo.co.uk/local/21001
No exact match found.
