Superantigens (SAgs) are a class of antigens that cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenic microbes (including viruses, mycoplasma, and bacteria) as a defense mechanism against the immune system. Compared to a normal antigen-induced T-cell re...
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http://en.wikipedia.org/wiki/Superantigen
<immunology> Antigens, mostly from bacterial toxins, that interact with a set of T lymphocytes bearing a set of products of the V_T receptor genes, as a consequence superantigens activate large numbers of T-cells. ... Staphylococcal enterotoxins are the best known superantigens and stimulate CD4 T-cells in humans. The Mls gene product in mice...
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http://www.encyclo.co.uk/local/20973
(soo″pәr-an´tĭ-jәn) any of a group of powerful antigens occurring in various bacteria and viruses that bind outside of the normal T cell receptor site and are able to react with multiple T cell receptor molecules, thus activating T cells nonspecifically. Included are staphylococcal enterotoxins and toxi...
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http://www.encyclo.co.uk/local/21001
Antigens, mostly of microbial origin, that activate all T-lymphocytes that have a T-cell receptor with a particular V b sequence; as a consequence superantigens activate large numbers of T-cells. Are presented on MHC Class II but are not processed and though they bind with high affinity, not in the groove of the MHC molecule where peptides are normally bound. Presentation is not MHC-restricted. Staphylococcal enterotoxins are the best known superantigens and stimulate CD4+ T-cells in humans. The Mls gene product in mice can act as a self-superantigen.
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http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Pronunciation: sū′pĕr-an′ti-jen Definitions: 1. An antigen that interacts with the T-cell receptor in a domain outside the antigen recognition site. This interaction induces the activation of larger numbers of T cells than are induced by antigens that are presented in the antigen recognition site leading to the rele...
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http://www.medilexicon.com/medicaldictionary.php?t=86683
class of exotoxin that triggers a strong nonspecific immune response with excessive production of cytokines (cytokine storm) causing inflammation, high fever, shock, and, potentially, death
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https://courses.lumenlearning.com/microbiology/chapter/glossary/
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