A drug used to treat some types of testicular cancer. It is also used to treat a higher-than-normal amounts of calcium in the blood or urine. Plicamycin binds to DNA and prevents cells from making RNA and proteins. It is a type of antineoplastic antibiotic. Also called Mithracin and mithramycin.
Found on
http://www.cancer.gov/dictionary?expand=P
<chemical> A tricyclic pentaglycosidic antibiotic from streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumours. Plicamycin is also used to reduce hypercalcaemia, especially that due to malignancies. ... Pharmacolo...
Found on
http://www.encyclo.co.uk/local/20973
(pli″kә-mi´sin) an antineoplastic antibiotic produced by Streptomyces plicatus that binds to DNA and inhibits RNA synthesis; it is used for treatment of advanced testicular carcinoma; major side effects are thrombocytopenia and hemorrhagic diathesis that can be life-threatening. It also has an inhibiting eff...
Found on
http://www.encyclo.co.uk/local/21001
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