==Mechanism== It is classified as a purine analog, which is a type of antimetabolite. It mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, interfering with the cell`s ability to process DNA. Cancer cells generally divide more often than healthy cells; DNA is highly involved in cell division (mitosis) and drugs whic....
Found on
http://en.wikipedia.org/wiki/Pentostatin
The active ingredient in a drug that is used to treat hairy cell leukemia and is being studied in the treatment of other types of cancer. Pentostatin blocks a protein needed for cell growth and may kill cancer cells. It is made by a bacterium. It is a type of adenosine deaminase inhibitor. Also called Nipent.
Found on
http://www.cancer.gov/dictionary?expand=P
<chemical> A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukaemia. It is also synergistic with some other antineoplastic agent and has immunosuppressive activity. ... Pharmacological action: antibiotics, antineoplastic, enzyme inhibitors, im...
Found on
http://www.encyclo.co.uk/local/20973
(pen″to-stat´in) a highly toxic antitumor antibiotic administered intravenously in the treatment of refractory hairy cell leukemia.
Found on
http://www.encyclo.co.uk/local/21001
No exact match found.
