==Mechanism== Metyrapone blocks cortisol synthesis by inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-deoxycortisol levels. ==Uses== Metyrapone can be used in the diagnosis of adrenal insufficiency. Metyrapone 30 mg/kg, maximum dose 3000 mg, is administered at midnight usually with a snack. Th...
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http://en.wikipedia.org/wiki/Metyrapone
<chemical> Chemical name: 1-Propanone, 2-methyl-1,2-di-3-pyridinyl- ... (12 Dec 1998) ...
Found on
http://www.encyclo.co.uk/local/20973
(mә-tēr´ә-pōn) a synthetic compound that selectively inhibits an enzyme responsible for the biosynthesis of corticosteroids; it is used as a diagnostic aid in a test of pituitary reserve.
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http://www.encyclo.co.uk/local/21001
Type: Term Pronunciation: mĕ-tir′ă-pōn Definitions: 1. An inhibitor of adrenocortical steroid C-11 β-hydroxylation, administered orally or intravenously to determine the ability of the pituitary gland to increase its secretion of corticotropin; because 11-deoxycorticosteroids, as a consequence of metyrapone administration,...
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http://www.medilexicon.com/medicaldictionary.php?t=55023
No exact match found.
