Abnormal coarseness or largeness of the ridgelike folds of the cerebralcortex (the gyri). ... (09 Oct 1997) ... 
(mak″ro-ji´re-ә) moderate reduction in the number of sulci of the cerebrum, sometimes with increase in the brain substance, resulting in excessive size of the gyri.
Type: Term Pronunciation: mak′rō-jī′rē-ă Synonyms: pachygyria