A reduction in the number of ganglionic nerve cells. ... (05 Mar 2000) ... 
(hi″po-gang″gle-ә-no´sis) deficiency in the number of myentericganglion cells in the distal segment of the large bowel, resulting in constipation; a variant of congenital megacolon (Hirschsprung disease).
Type: Term Pronunciation: hī′pō-gang′lē-on-ō′sis Definitions: 1. A reduction in the number of ganglionic nerve cells.