Fibronectin is a high-molecular weight (~440kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Similar to integrins, fibronectin binds extracellular matrix components such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans). Fibronectin exists as a protein dimer, co...
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http://en.wikipedia.org/wiki/Fibronectin
a glycoprotein which is found in the extracellular matrix and is important for the attachments, and therefore the movement of cells.
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http://www.encyclo.co.uk/local/20169
<protein> Glycoprotein of high molecular weight (2 chains each of 250 kD linked by disulphide bonds) that occurs in insoluble fibrillar form in extracellular matrix of animal tissues and soluble in plasma, the latter previously known as cold insoluble globulin. The various slightly different forms of fibronectin appear to be generated by tiss...
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(fi″bro-nek´tin) an adhesive glycoprotein: one form circulates in plasma and acts as an opsonin, and another is a cell-surface protein that mediates cellular adhesive interactions.
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Glycoprotein of high molecular weight (2 chains each of 250 kD linked by disulphide bonds) that occurs in insoluble fibrillar form in extracellular matrix of animal tissues, and soluble in plasma, the latter previously known as cold-insoluble globulin. The various slightly different forms of fibronectin appear to be generated by tissue-specific differential splicing of fibronectin mRNA, transcribed from a single gene. Fibronectins have multiple domains that confer the ability to interact with many extracellular substances such as collagen, fibrin and heparin, and also with specific membrane receptors on responsive cells. Notable is the RGD domain recognized by integrins, and two repeats of the EGF-like domain. The Fibronectin Type III domain (FnIII), about 90 amino acids long, of which there are 15 - 17 per molecule, is a common motif in many cell surface proteins. Interaction of a cell's fibronectin receptors (members of the integrin family) with fibronectin adsorbed to a surface results in adhesion and spreading of the cell.
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a fibrous protein that binds to collagen, fibrin, and other proteins and also to the cell membranes, functioning as an anchor and connector.
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https://www.infoplease.com/dictionary/fibronectin
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