Denervation: Loss of nerve supply. There are many causes of denervation. Denervation may be due to a disease as, for example, in polio where the death of motor neurons causes the denervation of muscle fibers. Denervation may be due to a chemical (such as botox) or physical injury or interruption of a nerve (as by accident or to relieve pain). Found on http://www.medterms.com/script/main/art.asp?articlekey=34015