<chemical> A renal dehydropeptidase-I and leukotriene d4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene d4 to leukeotri...
Found on
http://www.encyclo.co.uk/local/20973
(si″lah-stat´in) an enzyme inhibitor used with imipenem to decrease the metabolism of imipenem in the kidneys and increase its concentration in the urine; administered as the sodium salt.
Found on
http://www.encyclo.co.uk/local/21001
No exact match found.
