Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system. Antithrombin is a glycoprotein produced by the liver and consists of 432 amino acids. It contains three disulfide bonds and a total of four possible glycosylation sites. α-Antithrombin is the dominant form of antithrombin found in blood plasm...
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Any substance that inhibits or prevents the effects of thrombin in such a manner that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis. ... Antithrombin III, an antithrombin at present somewhat conjectural and biochemically not well ...
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(an″te-throm´bin) any naturally occurring or therapeutically administered substance that neutralizes the action of thrombin and thus limits or restricts blood coagulation. antithrombin I fibrin, referring to the capacity of fibrin to adsorb thrombin and thus neutralize it. ...
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An inhibitor of thrombin and activated Factor X.
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Type: Term Pronunciation: an′tē-throm′bin Definitions: 1. Any substance that inhibits or prevents the effects of thrombin in such a manner that blood does not coagulate. A deficiency of antithrombin results in impaired inhibition of coagulation factors IIa, IXa, and Xa in plasma, causing recurrent thrombosis.
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