Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent. It has been used in acute lymphoblastic leukemia. ==Mechanism== Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcri...
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http://en.wikipedia.org/wiki/Amsacrine
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
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http://www.cancer.gov/dictionary?expand=A
<chemical> N-(4-(9-acridinylamino)-3-methoxyphenyl)methanesulfonamide. Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukaemias and malignant lymphomas, but has poor activity in the treatment of solid tumours. It is frequently used in combination with other antineoplast...
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http://www.encyclo.co.uk/local/20973
(am´sә-krēn) an antineoplastic agent that inhibits DNA synthesis; used to treat some forms of leukemia.
Found on
http://www.encyclo.co.uk/local/21001
No exact match found.
