A substance made by cells that stimulates new blood vessel formation. Also called vascular endothelial growth factor.
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Synonym for vascular endothelial growth factor ... A growth factor that is responsible for the growth of blood vessels. ... (12 Dec 1998) ...
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vascular endothelial growth factor.
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(= vascular endothelial growth factor; vascular permeability factor; VPF) Growth factor of the PDGF family that stimulates mitosis in vascular endothelium, angiogenesis, and also increases permeability of endothelial monolayers. Tissue-specific splice variants (VEGF121, VEGF165, VEGF-C) are found, VEGF165 having heparin-binding activity which VEGF121 lacks. VEGF121 only binds to flk-1. Functional form is a dimer (or heterodimer of splice variants) that binds to flt-1 (VEGF-R1), flt-4 (VEGF- R3, binds only VEGF-C) or flk-1 (VEGF-R2/KDR) receptor tyrosine kinases. Can form heterodimer with placental growth factor (PLGF). See Tie and flt.
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Type: Abbreviation Definitions: 1. Abbreviation for vascular endothelial growth factor.
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VEGF: Vascular endothelial growth factor, a substance made by cells that stimulates the formation of new blood vessels, a process called angiogenesis. VEGF also acts as a mitogen for vascular endothelial (vessel lining) cells, stimulating these cells to divide and multiply. VEGF is a polypeptide. It is structurally related to platelet-derived growt...
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