Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. ==Uses== It has been used with leucovorin in treating pneumocystis pneumonia. It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acqu...
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http://en.wikipedia.org/wiki/Trimetrexate
<drug> An antibiotic approved as an alternative treatment for moderate-to-severe PCP. ... Trimetrexate causes severe bone marrow, liver, kidney and gastrointestinal toxicities. It must be administered along with leucovorin (folinic acid) to ameliorate these adverse effects. ... (19 Jan 1998) ...
Found on
http://www.encyclo.co.uk/local/20973
(tri″mә-trek´sāt) a folic acid antagonist structurally related to methotrexate, used as the glucuronate salt, in combination with leucovorin, to treat pneumocystis pneumonia in acquired immunodeficiency syndrome, administered intravenously.
Found on
http://www.encyclo.co.uk/local/21001
No exact match found.
