Topoisomerase

Topoisomerases (type I: {EC number|5.99.1.2}, type II: {EC number|5.99.1.3}) are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. For example, during DNA replication, DNA becomes overwound ahead of a replication fork. If left unabated, thi...
Found on http://en.wikipedia.org/wiki/Topoisomerase

topoisomerase

<enzyme> That change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA, type I topoisomerase of E. Coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA, type II topoisomerase of E. ...
Found on http://www.encyclo.co.uk/local/20973

topoisomerase

(to″po-i-som┬┤ә-rās) an enzyme involved in mobilization and replication of DNA during cell division.
Found on http://www.encyclo.co.uk/local/21001

Topoisomerase

Topoisomerase: A class of enzymes that alter the supercoiling of double-stranded DNA. (In supercoiling the DNA molecule coils up like a telephone cord, which shortens the molecule.) The topoisomerases act by transiently cutting one or both strands of the DNA. Topoisomerase type I cuts one strand whereas topoisomerase type II cuts both strands of th...
Found on http://www.medterms.com/script/main/art.asp?articlekey=32631

topoisomerase

Type: Term Pronunciation: tō′pō-i-som′ĕr-ās Definitions: 1. A type of enzyme converting (isomerizing) one topologic version of DNA into another; acts by catalyzing the breakage and reformation of DNA phosphodiester linkages.
Found on http://www.medilexicon.com/medicaldictionary.php?t=92620
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