P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-depend...
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http://en.wikipedia.org/wiki/P-glycoprotein
A protein that pumps substances out of cells. Cancer cells that have too much p-glycoprotein may not be killed by anticancer drugs.
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http://www.cancer.gov/dictionary?expand=P
<cell biology, protein> A family of integral plasma membrane proteins which, when overexpressed, function as adenosine triphosphate-dependent efflux pumps, causing multidrug resistance. ... Mammalian p-glycoproteins are encoded by small mdr gene families. There are several isotypes in multiple species. ... See: multidrug transporter. ... (22 ...
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http://www.encyclo.co.uk/local/20973
The first identified and best studied of the ABC drug transporters.
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http://www.encyclo.co.uk/local/22237
See multidrug transporter.
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http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Pronunciation: glī′kō-prō′tēn Definitions: 1. Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs. Synonyms: P-170
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http://www.medilexicon.com/medicaldictionary.php?t=67599
No exact match found.
