Synonym for myelofibrosis ... A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow in multiple sites outside the bone marrow. Typically, there is enlargement of the spleen and a gradual replacement of the bone marrow elements by fibrosis (scarring), progressive anaemia and variable changes in the number of...
(mi″ә-lo-sklә-ro´sis) sclerosis of the spinal cord. obliteration of the marrow cavity by small spicules of bone. myelofibrosis.
Type: Term Pronunciation: mī′ĕ-lō-sklēr-ō′sis Synonyms: myelofibrosis
build-up of fibrous connective tissue in the bone marrow, affecting the production of blood components 
Increased density of cancellous bone while cortical bone remains normal