holoprosencephaly

Type: Term Pronunciation: hol′ō-pros-en-sef′ă-lē Definitions: 1. Impaired midline cleavage of the embryonic forebrain resulting in a wide spectrum of facial features from cyclopia with proboscis above the single eye at the most severe form to ocular hypertelorism and single central upper incisor at the mildest form. This ...
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Holoprosencephaly

Holoprosencephaly: A relatively common birth defect of the brain, which often also affects facial features, causing closely spaced eyes, small head size, and sometimes clefts of the lip and roof of the mouth. Not all individuals with holoprosencephaly (HPE) are affected to the same degree, even in families where more than one individual has this pr...
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holoprosencephaly

Spectrum of craniofacial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. There are three types of malformations based on the degree of failure of separation of the prosencephalon: alobar, semilobar, and lobar. Concurrent facial anomalies can include cyclopia, cleft lip, cleft palate, an...
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holoprosencephaly

(hōl″o-pros″әn-sef┬┤ә-le) a developmental anomaly consisting of failure of cleavage of the prechordal mesoderm with a deficit in the forebrain and midline facial development; in the severe form there may be cyclopia. It is sometimes associated with trisomy 13 syndrome.
Found on http://www.encyclo.co.uk/local/21001

holoprosencephaly

holoprosencephaly Failure of the forebrain to divide into hemispheres or lobes causing insufficient development of facial characteristics; such as, the nose, lips, and palate; in severe cases, cyclopia can occur (a congenital defect characterized by fusion of the orbits into a single cavity containing one eye). Also called synophthalmia.
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Holoprosencephaly

A birth defect in which the forebrain does not properly divide into two hemispheres as it should. A child born with holoprosecephaly will have a single-lobed brain with severe defects of the skull and face. Babies with this condition have abnormalities of the eyes, nose and upper lip. Because of the severity of deformities that holoprosencephaly ca...
Found on http://www.pregnology.com/Pregnancy-dictionary/

Holoprosencephaly

Holoprosencephaly (HPE, once known as arhinencephaly) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. The condition also occurs in other species. The condition can...
Found on http://en.wikipedia.org/wiki/Holoprosencephaly
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