Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly). Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease. Systemic v...
<clinical sign> Abnormal enlargement of both the liver and the spleen, may be seen in cases of leukaemia, lymphoma, acute mononucleosis and others. ... (27 Sep 1997) ... 
(hep″ә-to-sple″no-meg´ә-le) enlargement of the liver and spleen.
Swollen liver and spleen.
Type: Term Pronunciation: hep′ă-tō-splē′nō-meg′ă-lē Definitions: 1. Enlargement of the liver and spleen. Synonyms: hepatolienomegaly
Hepatosplenomegaly:Enlargement of the liver and spleen. The word 'hepatosplenomegaly' is compounded from Greek roots: 'hepato-' from 'hepatikos' (of the liver) + 'spleno' from 'splen' (the spleen) + 'megaly' from 'megas' (big or great) = bigness of the liver and spleen.
Enlargement of the liver and spleen.
Enlargement of the liver and spleen.
hepatosplenomegaly Related 'big, large, great' words: grand-; macro-; magni-; major-; maxi-; megalo-. Related 'metric' families: yotta; zetta; exa; peta; tera; giga; kilo; hecto; deka; deci; centi; milli; micro; nano; pico; femto; atto; zepto; yocto.