==Fosinoprilat and Fosinopril== Fosinoprilat proved to have the same problem as enalaprilat and the other carboxylate-containing ACE inhibitors (namely poor oral bioavailability). Addition of a hydrophobic side-chain modulated the ionisation characteristics of the molecule making it more bioavailable. Fosinopril is administered as a prodrug and is...
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http://en.wikipedia.org/wiki/Fosinopril
<chemical> A phosphinic acid-containing angiotensin-converting enzyme inhibitor that is effective in the treatment of hypertension. It is a prodrug that is converted to its active metabolite fosinoprilat. ... Pharmacological action: angiotensin-converting enzyme inhibitors, antihypertensive agents. ... Chemical name: L-Proline, 4-cyclohexyl-1...
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http://www.encyclo.co.uk/local/20973
(fo-sin´o-pril) an angiotensin-converting enzyme inhibitor administered orally as the sodium salt to treat hypertension and congestive heart failure.
Found on
http://www.encyclo.co.uk/local/21001
No exact match found.
