Working from a flanking DNA marker, overlapping clones are successively identified that span a chromosomal region of interest. (See Chromosome.)
Found on
http://www.encyclo.co.uk/local/20095
A procedure to find and sequence a gene whose approximate position in a chromosome is known by classical genetic linkage studies. Starting with the known sequence of a gene shown by classical genetics to be near to the novel gene, new clones are picked from a genomic library by hybridisation with a short probe generated from the appropriate end of ...
Found on
http://www.encyclo.co.uk/local/20973
A procedure to find and sequence a gene whose approximate position in a chromosome is known by classical genetic linkage studies. Starting with the known sequence of a gene shown by classical genetics to be near to the novel gene, new clones are picked from a genomic library by hybridization with a short probe generated from the appropriate end of the known sequence. The new clones are then sequenced, new probes generated, and the process repeated until the gene of interest is reached.
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Found on
http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Definitions: 1. sequential isolation of overlapping sequences of DNA (clones); with this procedure large regions of the chromosome can be spanned. Synonyms: overlap hybridization
Found on
http://www.medilexicon.com/medicaldictionary.php?t=17503
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