
1) Chemical irritant
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https://www.crosswordclues.com/clue/capsaicin

Capsaicin (n; 8-methyl-N-vanillyl-6-nonenamide) is an active component of chili peppers, which are plants belonging to the genus Capsicum. It is an irritant for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact. Capsaicin and several related compounds are called capsaicinoids and are prod...
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http://en.wikipedia.org/wiki/Capsaicin

a substance found in some plant products, especially hot peppers, which causes human nerves to report a hot sensation.
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http://en.wikipedia.org/wiki/Glossary_of_diabetes

• (n.) A colorless crystalline substance extracted from the Capsicum annuum, and giving off vapors of intense acridity.
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http://thinkexist.com/dictionary/meaning/capsaicin/

the most abundant of the pungent principles of the red pepper (Capsicum). It is an organic nitrogen compound belonging to the lipid group, but it is ... [2 related articles]
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http://www.britannica.com/eb/a-z/c/21

A component of certain plants, including cayenne and red pepper, used topically for peripheral nerve pain. It is also being studied for controlling mucositis pain after chemotherapy and radiation therapy.
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http://www.cancer.gov/dictionary?expand=C

an ingredient in hot peppers that can be found in ointment form for use on the skin to relieve pain from diabetic neuropathy.
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http://www.diabetes.co.uk/glossary/c.html

an ingredient in hot peppers that can be found in ointment form for use on the skin to relieve pain from diabetic
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http://www.diabetes.org

<chemical> Trans-8-methyl-n-vanillyl-6-nonenamide. Cytotoxic alkaloid from various species of capsicum (pepper, paprika), of the solanaceae; causes pain, irritation and inflammation;, due to substance p depletion from sensory (afferent) nerve fibres; used mainly to study the physiology of pain and in the form of capsicum as a counterirritant ...
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http://www.encyclo.co.uk/local/20973

(kap-sa´ĭ-sin) a plant alkaloid irritating to the skin, the active ingredient of capsicum; used in a cream as a counterirritant and topical analgesic, and also used in pepper spray.
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http://www.encyclo.co.uk/local/21001

(= 8-methyl-N-vanillyl-6-nonenamide) Molecule in chilli peppers that makes them hot and will stimulate release of neurogenic peptides (Substance P, neurokinins) from sensory neurons. Acts on the vanilloid receptor-1 (VR1). Can be used to desensitise nociceptors to which it binds - and which may eventually be killed.
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http://www.encyclo.co.uk/visitor-contributions.php
Cap·sa'i·cin noun [ From
Capsicum .]
(Chemistry) A colorless crystalline substance extracted from the
Capsicum annuum , and giving off vapors of intense acridity.
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http://www.encyclo.co.uk/webster/C/21

Type: Term Pronunciation: kap-sā′i-sin Definitions: 1. Alkaloidal principle in the fruits of various species of Capsicum, with the same uses. It depletes substance P from sensory nerve endings; sometimes used for pain in postherpetic neuralgia.
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http://www.medilexicon.com/medicaldictionary.php?t=14023

Capsaicin: A component of certain plants, including cayenne and red pepper, used topically to relieve minor arthritis pain and nerve pain. Capsaicin is in creams such as Arthricare and Zostrix that are applied to the skin. It appears to work by reducing a chemical substance found at nerve endings that is involved in transmitting pain signals to the...
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http://www.medterms.com/script/main/art.asp?articlekey=33741

[
n] - colorless pungent crystalline compound derived from capsicum
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http://www.webdictionary.co.uk/definition.php?query=capsaicin
noun colorless pungent crystalline compound derived from capsicum; source of the hotness of hot peppers of the genus Capsicum such as chili and cayenne and jalapeno
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https://www.encyclo.co.uk/local/20974
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