Alexander disease, also known as fibrinoid leukodystrophy, is a slowly progressing and fatal neurodegenerative disease. It is a very rare disorder which results from a genetic mutation and mostly affects infants and children, causing developmental delay and changes in physical characteristics. ==Cause== Alexander disease is a genetic disorder affe...
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http://en.wikipedia.org/wiki/Alexander_disease
<radiology> Dysmyelinating disease, rare, sporadic, usually presents in 1st year, gradual enlargement of head (Differential diagnosis: Canavan disease), retardation, convulsion, spasticity CT findings: decreased density of white matter, frontal lobe predominance, with or without dilated lateral ventricles Diagnosis: brain biopsy ... (12 Dec 1...
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(al″eg-zan´dәr) an infantile form of leukodystrophy, characterized histologically by the presence of eosinophilic material at the surface of the brain and around its blood vessels, resulting in brain enlargement.
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http://www.encyclo.co.uk/local/21001
Type: Term Pronunciation: al-ek-zan′dĕr Definitions: 1. a rare, fatal degenerative disease of the central nervous system of infants, characterized by psychomotor retardation, seizures, and paralysis; megaloencephaly is associated with widespread leukodystrophic changes, especially in the frontal lobes.
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http://www.medilexicon.com/medicaldictionary.php?t=25257
Alexander disease: A slowly progressive and ultimately fatal brain disorder that most commonly occurs in children. The infantile form of the disease is characterized by megalencephaly (an abnormally large head), seizures, spasticity and developmental retardation. It leads to death usually within the first decade. Patients with the juvenile and adul...
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