Valinomycin is a dodecadepsipeptide antibiotic. Valinomycin is obtained from the cells of several Streptomyces strains, among which `S. tsusimaensis` and S. fulvissimus. It is a member of the group of natural neutral ionophores because it does not have a residual charge. It consists of enantiomers D- and L-valine (Val), D-alpha-hydroxyisovaleric.....
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<drug> A potassium ionophore antibiotic, produced by Streptomyces fulvissimus. Composed of 3 molecules (L valine, D _ hydroxyisovaleric acid, L lactic acid) linked alternately to form a 36 membered ring, that folds to make a cage shaped like a tennis ball seam. This wraps specifically around potassium ions, presenting them with a hydrophilic ...
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A potassium ionophore antibiotic, produced by Streptomyces fulvissimus . Composed of 3 molecules (L-valine, D -a- hydroxyisovaleric acid, L-lactic acid) linked alternately to form a 36-membered ring, that folds to make a cage shaped like a tennis-ball seam. This wraps specifically around potassium ions, presenting them with a hydrophilic interior, and a lipid bilayer with a hydrophobic exterior. Potassium is thus free to diffuse through the lipid bilayer. Highly ion specific, valinomycin is used in ion-selective electrodes.
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Type: Term Pronunciation: val′i-nō-mī′sin Definitions: 1. Cyclododecadepsipeptide ionophore antibiotic derived from Streptomyces fulvissius; used as an insecticide and nematocide.
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