Tunicamycin is a mixture of homologous nucleoside antibiotics that inhibits the UDP-HexNAc: polyprenol-P HexNAc-1-P family of enzymes. In eukaryotes, this includes the enzyme GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glyco...
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http://en.wikipedia.org/wiki/Tunicamycin
<drug> Nucleoside antibiotics from Streptomyces lysosuperificus that act in eukaryotic cells to inhibit N glycosylation. ... Tunicamycin inhibits the first step in synthesis of the dolichol linked oligosaccharide, by preventing the addition of N acetylglucosamine to dolichol phosphate. ... (18 Nov 1997) ...
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http://www.encyclo.co.uk/local/20973
Nucleoside antibiotics from Streptomyces lysosuperificus that act in eukaryotic cells to inhibit N-glycosylation. Tunicamycin inhibits the first step in synthesis of the dolichol-linked oligosaccharide, by preventing the addition of N-acetyl glucosamine to dolichol phosphate.
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http://www.encyclo.co.uk/visitor-contributions.php
No exact match found.
