Thapsigargin is non-competitive inhibitor of a class of enzymes known by the acronym SERCA, which stands for sarco / endoplasmic reticulum Ca2+ ATPase. Structurally, thapsigargin is classified as a sesquiterpene lactone, and is extracted from a plant, Thapsia garganica. It is a tumor promoter in mammalian cells. The anti-malarial drug artemisinin ...
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http://en.wikipedia.org/wiki/Thapsigargin
<protein> Cell permeable inhibitor of calcium ATPase of endoplasmic reticulum, leads to increase in cytoplasmic calcium ions. Acts independently of InsP3. A tumour promoter. ... (18 Nov 1997) ...
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http://www.encyclo.co.uk/local/20973
Cell-permeable inhibitor of calcium ATPase of endoplasmic reticulum; leads to increase in cytoplasmic calcium ions. Acts independently of InsP3. A tumour promoter.
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Type: Term Pronunciation: thap-si-gar′jin Definitions: 1. a highly potent and selective inhibitor of sarcoendoplasmic reticulum family of Ca2+-ATPases used in research on intracellular calcium stores.
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http://www.medilexicon.com/medicaldictionary.php?t=91149
No exact match found.
