Syndecans are single transmembrane domain proteins that are thought to act as coreceptors, especially for G protein-coupled receptors. These core proteins carry three to five heparan sulfate and chondroitin sulfate chains, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth f...
Found on
http://en.wikipedia.org/wiki/Syndecan
<protein> An integral membrane proteoglycan (250-300 kD) associated largely with epithelial cells. ... The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular domain has up to three heparan sulphate and two chondroitin or dermatan sulphate chains...
Found on
http://www.encyclo.co.uk/local/20973
An integral membrane proteoglycan (250-300 kD) associated largely with epithelial cells. The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular domain has up to three heparan sulphate and two chondroitin or dermatan sulphate chains plus an N-linked oligosaccharide. The heparan sulphate chains bind to several proteins of the extracellular matrix, including collagens, fibronectin and tenascin. The cytoplasmic domain is thought to interact with actin filaments. Its name is derived from the Greek syndein , to bind together. Ligation of N-syndecan (syndecan-3) by heparin-binding growth-associated molecule increases phosphorylation of c-src and cortactin, and N-syndecan may act as a neurite outgrowth receptor.
...
Found on
http://www.encyclo.co.uk/visitor-contributions.php
Syndecan: One of a family of core proteins with sugars attached to the cell surfaces that control or influence tissue repair, metabolism, the formation of tumors and the development of immune responses. The name is derived from the Greek syndein, to bind together. There are 4 known members of the syndecan family. All are proteoglycans (molecules co...
Found on
http://www.medterms.com/script/main/art.asp?articlekey=20178
No exact match found.
