(from the article `Ciechanover, Aaron J.`) ...to a protein targeted for destruction and accompanies it to a proteasome—essentially a sac of powerful enzymes that break the protein into its ... ...meaning `everywhere,` because it occurs in so many different cells and organisms) attaches itself to the protein targeted for d...
Found on
http://www.britannica.com/eb/a-z/p/122
<cell biology> Proteolytic complexes that degrade cytosolic and nuclear proteins. Implicated in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different pep...
Found on
http://www.encyclo.co.uk/local/20973
Type: Term Pronunciation: prō′tē-ă-sōm Definitions: 1. Cytoplasmic organelle, composed of a cylindric core particle bound by two regulatory particles at each end, responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targ...
Found on
http://www.medilexicon.com/medicaldictionary.php?t=72929
Proteasome: A protein degradation 'machine' within the cell that can digest a variety of proteins into short polypeptides and amino acids. The proteasome is itself made up of proteins. It requires ATP to work. It is hollow and has openings at both ends to allow entry of the protein to be digested. A human cell contains about 30,000 proteasomes. The...
Found on
http://www.medterms.com/script/main/art.asp?articlekey=32245
No exact match found.
