Myristoylation is an irreversible, protein lipidation modification where a myristoyl group, derived from myristic acid, is covalently attached by an amide bond to the alpha-amino group of an N-terminal glycine residue. Myristic acid is a 14-carbon saturated fatty acid (14:0) with the systematic name of n-Tetradecanoic acid. This modification can b...
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http://en.wikipedia.org/wiki/Myristoylation
Synonym for myristic acid ... <biochemistry> The myristoyl group is one of the less common fatty acyl residues of phospholipids in biological membranes but is found as an N terminal modification of a large number of membrane associated proteins and some cytoplasmic proteins. ... It is a common modification of viral proteins. In all known exam...
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http://www.encyclo.co.uk/local/20973
Many proteins in eukaryotes are covalently attached to myristic acid in membranes through amide linkages formed by myristoyl CoA:protein N-myristoyl transferase (NMT), at a glycine, with a consensus site: G-(EDRKHPFYW)-x-x-(STAGCN)-P. This allows a range of enzymes to be concentrated in specific domains within the cell.
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