It was isolated from the mold Penicillium citrinum by Akira Endo in the 1970s and he identified it as a HMG-CoA reductase inhibitor, i.e.; a statin. Mevastatin might be considered the first statin drug, but, although clinical trials on mevastatin were performed in the late 1970s in Japan, it was never marketed. The first statin drug available to t...
Found on
http://en.wikipedia.org/wiki/Mevastatin
Fungal metabolite which is a potent inhibitor of HMG-CoA reductase, the rate-controlling enzyme in cholesterol biosynthesis. The drug, similar to lovastatin, pravastatin and simvastatin, is used in the treatment of hyperlipidemia. ... (05 Mar 2000) ...
Found on
http://www.encyclo.co.uk/local/20973
No exact match found.
