
Megalencephaly (or Macrencephaly abbreviated MEG) is a growth development disorder in which the brain is abnormally large. It is characterized by a brain with an average weight that is 2.5 standard deviations from the mean of the general population. Megalencephaly is usually diagnosed at birth and is confirmed with an MRI. A mutation in the PI3K-A...
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http://en.wikipedia.org/wiki/Megalencephaly

Having a brain of unusually large size.
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http://www.encyclo.co.uk/local/20898

(meg″әl-әn-sef´ә-le) macrencephalia; hypertrophy of the brain.
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Megalencephaly: Also called macrencephaly, a condition in which there is an abnormally large, heavy, and usually malfunctioning brain. By definition, the brain weight is greater than average for the age and gender of the child. Head enlargement may be evident at birth or the head may become abnormally large in the early years of life. Megalencephal...
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http://www.medterms.com/script/main/art.asp?articlekey=15544

A birth defect that causes an infant to be born with a very large head and malfunctioning brain. Occasionally the infant will not be born with an abnormally large head when megalencephaly is present. In this case, the head will rapidly grow during the child's early years. Common symptoms of megalencephaly include developmental delays, seizures, con...
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megalencephaly A condition in which there is an abnormally large, heavy, and usually malfunctioning brain. By definition, the brain weight is greater than average for the age and sex of the infant or child. Head enlargement may be evident at birth or the head may become abnormally large in the early years of life; also called macrencephaly.
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