Glucarpidase (Voraxaze) is a FDA-approved intravenous drug for the treatment of elevated levels of methotrexate (defined as 1 micromol/L) during treatment of cancer patients who have impaired kidney function (and thus can`t reduce the drug to safe levels sufficiently after the drug has been given). Glucarpidase is an enzyme that inactivates metho....
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http://en.wikipedia.org/wiki/Glucarpidase
A bacterial enzyme that breaks down proteins and other substances, including methotrexate. It is being studied in the treatment of toxic effects caused by methotrexate. It may also help activate certain drugs to kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator. Also called carboxypeptidase-G2.
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http://www.cancer.gov/dictionary?expand=G
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