<cell biology> Heavily glycosylated membrane glycoprotein. Encoded by the MUC 1 gene, has a molecular weight of around 300 kD, more than half of which is O linked glycan. There is a 69 residue cytoplasmic domain and the extracellular domain may extend hundreds of nanometres beyond the plasma membrane, the increased expression in carcinoma cel...
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http://www.encyclo.co.uk/local/20973
(= polymorphic epithelial mucin, PEM; epithelial membrane antigen, EMA) Heavily glycosylated membrane glycoprotein. Encoded by the MUC- 1 gene; has a molecular weight of around 300 kD, more than half of which is O -linked glycan. There is a 69 residue cytoplasmic domain and the extracellular domain may extend hundreds of nanometres beyond the plasma membrane; the increased expression in carcinoma cells may reduce the adhesion and mask antigenic properties of the cells. Similar functions are ascribed to ASGP, epiglycanin and leukosialin.
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