Echinomycin is a peptide antibiotic. It intercalates into DNA at two specific sites, thereby blocking the binding of hypoxia inducible factor 1 alpha (HIF1alpha). == Biosynthesis == Echinomycin is a bis-intercalator peptide and is biosynthesized by a unique nonribosomal peptide synthetase (NRPs). Echinomycin is isolated from various bacteria such ...
Found on
http://en.wikipedia.org/wiki/Echinomycin
<chemical> A toxic polypeptide quinoxaline antibiotic isolated from streptomyces echinatus that binds to DNA and inhibits RNA synthesis. It has antitumour and antibacterial activity. ... Pharmacological action: antibiotics, antineoplastic, antibiotics, peptide, nucleic acid synthesis inhibitors. ... Chemical name: Quinomycin A ... (12 Dec 199...
Found on
http://www.encyclo.co.uk/local/20973
No exact match found.
