• (v. t.) To render unacquainted; to make unfamiliar.
Dis`ac·quaint' transitive verb [ Prefix dis- + acquaint : confer Old French desacointier .] To render unacquainted; to make unfamiliar. [ Obsolete] « While my sick heart With dismal smart Is disacquainted never.» Herrick. 
disacquaint To render unacquainted; to make unfamiliar.