In sterol synthesis, cerulenin inhibits HMG-CoA synthetase activity. It was also reported that cerulenin specifically inhibited fatty acid biosynthesis in Saccharomyces cerevisiae without having an effect on sterol formation. But in general conclusion, cerulenin has inhibitory effects on sterol synthesis. Cerulenin causes a dose-dependent decrease...
Found on
http://en.wikipedia.org/wiki/Cerulenin
<chemical> 2,3-epoxy-4-oxo-7,10-dodecadionamide. Antifungal antibiotic isolated from several species, including acremonium (cephalosporium), acrocylindrum, and helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function and is used as a biochemical tool. ... Pharmacological action: antibiotics, antifungal.
Found on
http://www.encyclo.co.uk/local/20973
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