==Structures== CPT has a planar pentacyclic ring structure, that includes a pyrrolo[3,4-β]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring). Its planar structure is thought to be one of the most important factors ...
Found on
http://en.wikipedia.org/wiki/Camptothecin
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
Found on
http://www.cancer.gov/dictionary?expand=C
This alkaloid was originallyisolated from a Chinese tree, Camptotheca acuminata but has alsobeen found in the nothapodytes tree (Nothapodytes foetida). It isthe first known naturally-produced DNA topoisomerase Iinhibitor, and as such is being heavilly researched as atreatment for a wide variety of cancers. ... (09 Oct 1997) ...
Found on
http://www.encyclo.co.uk/local/20973
Cytotoxic plant alkaloid originally isolated from Camptotheca acuminata . Anti-cancer drug, inhibits DNA topoisomerase I.
Found on
http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Pronunciation: kamp′tō-thek′in Definitions: 1. Plant alkaloids consisting of a pentacyclic structure with a lactone ring; inhibitors of topoisomerase I, topotecan and irinotecan (CPT-11).
Found on
http://www.medilexicon.com/medicaldictionary.php?t=13561
No exact match found.
