Caldesmon is a protein that in humans is encoded by the CALD1 gene. ...
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http://en.wikipedia.org/wiki/Caldesmon
<protein> Protein originally isolated from smooth muscle (h caldesmon, 120-150 kD on gels but 88.7 kD from sequence) also found in nonmuscle cells (l caldesmon, 70-80 kD on gels but 58.8 kD from sequence). Normally dimeric, binds to F actin blocking the myosin binding site. Calcium calmodulin binding to caldesmon causes its release from actin...
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http://www.encyclo.co.uk/local/20973
Protein originally isolated from smooth muscle (h-caldesmon; 120-150 kD on gels but 88.7 kD from sequence) also found in non-muscle cells (l-caldesmon; 70-80 kD on gels but 58.8 kD from sequence). Normally dimeric, binds to F-actin blocking the myosin binding site. Calcium-calmodulin binding to caldesmon causes its release from actin, though phosphorylation of caldesmon may also affect the link with actin. Caldesmon can block the effect of gelsolin on F-actin and will dissociate actin-gelsolin complexes and actin-profilin complexes.
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http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Pronunciation: kal-des′mon Definitions: 1. An F-actin cross-linking protein that, at low or absent calcium levels, binds to tropomyosin and actin and prevents myosin binding.
Found on
http://www.medilexicon.com/medicaldictionary.php?t=13406
No exact match found.
