bungarotoxins

Toxins found in the venom of Bungarus multicinctus . a -bungarotoxin: polypeptide toxin (74 residues). A powerful antagonist of acetylcholine it causes virtually irreversible block of the vertebrate neuromuscular junction by binding (as a monomer) to each of the a -subunits of the postsynaptic nicotinic acetycholine receptors (nAChR) Has been much used in identifying, quantifying and localizing these receptors on muscle cells. Will also bind some neuronal nAChR ; b -bungarotoxin: a two-chain phospholipase A2 neurotoxin that acts at the presynaptic site of motor nerve terminals and blocks transmitter release. Subunit A (120 residues) is structurally homologous to other PLA2s, the B subunit (60 residues) has homology with Kunitz-type serine protease inhibitors and dendrotoxins. Binds to subtype of voltage-sensitive potassium channels. k -bungarotoxin: (bungarotoxin 3.1; Toxin F, neuronal bungarotoxin) is a polypeptide (66 residues) from the venom of Bungarus multicinctus . Has considerable homology with a -bungarotoxin. Functional toxin a homodimer. Potent antagonist for a subset of neuronal nAChR but is much less active against muscle receptors. ...

bungarotoxins

Neurotoxic proteins from the venom of the banded or formosan krait (bungarus multicinctus, an elapid snake). ... Alpha-bungarotoxin blocks nicotinic acetylcholine receptors and has been used to isolate and study them; beta- and gamma-bungarotoxins act presynaptically causing acetylcholine release and depletion. Both alpha and beta forms have been c...
Found on http://www.encyclo.co.uk/local/20973

bungarotoxins

Type: Term Pronunciation: bung′gă-rō-tok′sinz Definitions: 1. Constituent proteins of the venom of the southern Asian banded krait Bungarus multicinctus, a snake of the Elapidae family. Used as pharmacologic tools in studying neuromuscular function.
Found on http://www.medilexicon.com/medicaldictionary.php?t=12817
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