Arrestins are a small family of proteins important for regulating signal transduction. ==Function== Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn and co-workers and in the β-adrenergic system by Martin J...
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http://en.wikipedia.org/wiki/Arrestin
A 48-kD protein of the outer segment of the retinal rods and a component of the phototransduction cascade. Arrestin quenches g-protein activation by binding to phosphorylated photolyzed rhodopsin. Arrestin causes experimental autoimmune uveitis when injected into laboratory animals. ... (12 Dec 1998) ...
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http://www.encyclo.co.uk/local/20973
Family of inhibitory proteins that bind to tyrosine-phosphorylated receptors, thereby blocking their interaction with G-proteins and effectively terminating the signalling. Arrestin (S antigen; 48 kD, from retinal rods) competes with transducin for light-activated rhodopsin, thus inhibiting the response to light (adaptation). Immune responses to arrestin lead to autoimmune uveitis. Similarly, b -arrestin binds to phosphorylated b -adrenergic rece …
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http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Pronunciation: ar′res-tin Synonyms: S antigen2
Found on
http://www.medilexicon.com/medicaldictionary.php?t=6374
No exact match found.
