Aphidicolin is defined as a tetracyclic diterpene antibiotic isolated from the fungus, Cephalosporum aphidicola with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase A,D in eukaryotic cells and...
Found on
http://en.wikipedia.org/wiki/Aphidicolin
<chemical> Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11ah-cyclohepta(a)naphthalene-4,9-dimethanol. ... An antiviral antibiotic produced by cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or t...
Found on
http://www.encyclo.co.uk/local/20973
(1) Inhibitor of eukaryotic DNA polymerases. (2) tetracyclic diterpenoid from Cephalosporium.
Found on
http://www.encyclo.co.uk/visitor-contributions.php
No exact match found.
