
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a `peak level`, which is the highest level of the medicine in the b.....
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http://en.wikipedia.org/wiki/Trough_level

the lowest level of a drug reached between doses. Contrast with peak level.
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http://www.encyclo.co.uk/local/22225
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