(from the article `tumour suppressor gene`) ...Subsequent research revealed that mutations in this gene also play a role in cancers of the bone, lung, breast, cervix, prostate, and bladder. A ... The p53 protein was discovered in 1979. It resides in the nucleus, where it regulates cell proliferation and cell death. In particular, it pre...
Found on
http://www.britannica.com/eb/a-z/p/1
<molecular biology, oncogene> A gene which encodes a protein that regulates cell growth and is able to cause potentially cancerous cells to destroy themselves. ... In humans it is a 393 residue phosphoprotein that is a tumour suppressor gene rather than an oncogene, as it is frequently inactivated or mutated in tumours and transformed cells.
Found on
http://www.encyclo.co.uk/local/20973
A 393 residue (in humans) phosphoprotein that is a common tumour antigen, expressed in many transformed cells. However, it is believed to be the product of a tumour suppressor gene, rather than an oncogene, as it is frequently inactivated or mutated in tumours. See Table O1.
Found on
http://www.encyclo.co.uk/visitor-contributions.php
Type: Term Definitions: 1. A tumor suppressor gene located on the short arm of chromosome 17 that encodes a nucleophosphoprotein that binds DNA and negatively regulates cell division; frequently measured as a marker of malignant diseases.
Found on
http://www.medilexicon.com/medicaldictionary.php?t=64311
p53: A tumor suppressor. The designation 'p53' stands for 'protein 53 kilodaltons' in size. p53 is a specific protein produced by a gene that functions to suppress the growth of tumors. The p53 gene is the most commonly mutated gene known in human cancer. Like other tumor-suppressor genes, p53 normally controls cell growth. If p53 is physically los...
Found on
http://www.medterms.com/script/main/art.asp?articlekey=4718
A tumour supressor gene that, when working normally, helps to stop cells becoming cancerous. The p53 gene has been found to be damaged in most human cancers.
Found on
https://www.encyclo.co.uk/local/20753
No exact match found.
