Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. Because it has gla domains, its synthesis is vitamin K dependent. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. == Function == Osteocalcin is secreted solely by osteoblasts ...
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a calcium binding protein, synthesised by the osteoblast and secreted into the matrix at the time of bone mineralisation. Mice bread without the osteocalcin gene develop heavy bones suggesting that osteocalcin is a negative regulator of bone formation
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http://www.encyclo.co.uk/local/20169
<protein> Polypeptide of 50 residues formed from a 76-77 amino acid precursor and found in the extracellular matrix of bone. Binds hydroxyapatite. Has limited homology of its leader sequence with that of other Vitamin K dependent proteins such as prothrombin, Factors IX and X and Protein C. ... (18 Nov 1997) ...
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http://www.encyclo.co.uk/local/20973
(= bone g-carboxyglutamic acid protein: BGP) Polypeptide of 50 residues formed from a 76-77 amino acid precursor, and found in the extracellular matrix of bone. Binds hydroxyapatite. Has limited homology of its leader sequence with that of other vitamin K-dependent proteins such as prothrombin, Factors IX and X, and Protein C.
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Type: Term Pronunciation: os′tē-ō-kal′sin Definitions: 1. A protein found in osteoblasts and dentin; contains γ-carboxyglutamyl residues; has a role in mineralization and calcium ion homeostasis. Synonyms: bone Gla protein
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