Melittin is the principal active component of apitoxin (bee venom) and is a powerful stimulator of phospholipase A2. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. == Biological effects == Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and...
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http://en.wikipedia.org/wiki/Melittin
<protein> The major component of bee venom, responsible for the pain of the sting. ... A 26 amino acid peptide, that has a hydrophobic and a positively charged region. Can lyse cell membranes and activate phospholipase A2 enzymes, it has a very high affinity for calmodulin but the biological relevance of this is unclear. ... (13 Nov 1997) ......
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http://www.encyclo.co.uk/local/20973
The major component of bee venom, responsible for the pain of the sting. A 26-amino acid peptide, that has a hydrophobic and a positively-charged region. Can lyse cell membranes and activate phospholipase A2 enzymes; it has a very high affinity for calmodulin but the biological relevance of this is unclear.
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Type: Term Pronunciation: mel′i-tin Definitions: 1. The principal component in bee venom; melittin is a peptide amide containing 26 amino acyl residues and is a hemolysin.
Found on
http://www.medilexicon.com/medicaldictionary.php?t=53770
Melittin: The principal toxic component in bee venom. Melittin is a relatively short peptide consisting of 26 amino acids. It is a powerful cell lytic agent and binds rapidly to red blood cells causing the release of hemoglobin in the blood plasma. Lysis of these cells occurs when the organization of a lipid bilayer is perturbed.
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http://www.medterms.com/script/main/art.asp?articlekey=40544
No exact match found.
